TRANSLATIONAL PHYSIOLOGY Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis
نویسندگان
چکیده
Fina Lovren, Yi Pan, Praphulla C. Shukla, Adrian Quan, Hwee Teoh, Paul E. Szmitko, Mark D. Peterson, Milan Gupta, Mohammed Al-Omran, and Subodh Verma Division of Cardiac Surgery, Keenan Research Centre, Li Ka Shing Knowledge Institute, Division of General Internal Medicine, and Cardiometabolic Risk Initiative, St. Michael’s Hospital, Toronto; Canadian Cardiovascular Research Network, Toronto; Translational Traineeship Program in Atherosclerosis, Toronto; Division of Cardiology, William Osler Health Centre, Brampton, Ontario, Canada; and Division of Vascular Surgery, College of Medicine and King Khalid University Hospital, King Saud University-Li Ka Shing Collaborative Research Program, Riyadh, Kingdom of Saudi Arabia
منابع مشابه
Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis.
Improving endothelial nitric oxide synthase (eNOS) bioactivity and endothelial function is important to limit native, vein graft, and transplant atherosclerosis. Visfatin, a NAD biosynthetic enzyme, regulates the activity of the cellular survival factor, Sirt1. We hypothesized that visfatin may improve eNOS expression, endothelial function, and postnatal angiogenesis. In human umbilical vein (H...
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